In some places, some people absolutely could not endure the long travels to the West Coast, for example the Oregon Trail was extremely difficult and many people quit somewhere in the middle and settled into those Midwestern states. Yes they did in fact get tired, in some situations.
What was so special about Oregon, anyway, that it was worth a deadly trek across the country to go there?
Wasn't it just that it wasn't yet settled, so you could settle there and claim some land? That implies that Indiana or anywhere else on the way would have been at least as desirable, but someone else got there first.