This all the way. If you are trying to design a web page with usability in mind, the most important thing to do is make sure on the default 16:9 or 16:10 screen everyone is using that the content dominates the page with the least navigation overhead as possible. That is the main reason why I prefer sites that use vertical sidebars to horziontal top of the page navigation frames that take up 1/3 the initial load.