In academic biology, it is pretty common to put in stupid long hours and a lot of weekend work. However, we always had a running joke that "weekend work never works".

Basically, that experiment you are running on the weekend - so you can get that critical data a few days quicker - will invariably fail to produce any data at all. It is doomed before you start. We were never sure if it was due to tiredness and fatigue, your mind subconsciously sabotaging you or the angry science gods.

But it never worked. You were guaranteed to waste your weekend doing something that had to be repeated on Monday.

So, I'm agreeing with patrickyeon. Is soldering that PCB board really important right now? Do you really need to run that experiment this weekend?