It is indeed unlikely. But if we can actually get to the point that 2^10 web clients (1024) are as strong as Houdini or Rybka on one high-end hardware, it won't be that hard to double the size of the web grid a couple more times.
As you pointed out, the main challenge is scaling efficiently, and not getting a poor speedup even with that many workers (I think we can aim for 60% speedup with YBWC). We hope to have an edge here with Node.js' I/O performance, but it's still a big challenge (and that's what keeps it interesting ;-)
Note that most top engines barely get this speedup with 4 cores on an SMP system. I doubt you can get the same efficiency in a distributed system with 2000 cores.
As you pointed out, the main challenge is scaling efficiently, and not getting a poor speedup even with that many workers (I think we can aim for 60% speedup with YBWC). We hope to have an edge here with Node.js' I/O performance, but it's still a big challenge (and that's what keeps it interesting ;-)