My co-workers swear by Flux, mainly because they only code. But as the designer in the team, I'd have to disable it every time I'm working on a design.
I actually edit photos even while Flux is on. Eyes are amazing things; mine adjust to the new white balance and I can still judge colors reasonably well (ok, as well as I could before). Of course, these are just photos for Flickr, not for professional work, but when I compare the ones edited with Flux on and with Flux off, I can't tell the difference. In other words, might be worth a try anyway.
Your eyes adapt to the new color temperature very quickly. If you have a good-enough screen and/or you're not working on something with a lot of dynamic in the red spectrum, you should be fine. Even if not, you might still be just fine. I do photo post-processing with flux on and haven't seen a difference in the finished product, same for print and web design work. You get used to flux really quickly.
